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. 2018 Nov 8;5:163. doi: 10.3389/fcvm.2018.00163

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Copyright © 2018 Chellan, Sutton and Hofmann Bowman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enzyme modified LDL (ELDL), but not acetylated (acLDL) or oxidized LDL (oxLDL) induces foam cell formation in murine SMCs, in contrast to macrophages which readily take up acLDL, oxLDL and ELDL. In, (A) Oil Red O staining for peritoneal macrophages (upper) and for aortic SMCs (lower) stimulated with 10 μg/ml modified LDL as indicated. (B) Quantification of intracellular cholesterol. (C) Oil Red O staining of aortic SMC stimulated with different concentration of LDLs as indicated and quantified in (D). Reproduced with permission from Lippincott Williams and Wilkins (61). **p < 0.01.