Table 1.
Clinical-biochemical data in participates after L. reuteri consumption.
| placeboa | ADR-1a | P-valueb | ADR-3a | P-valueb | ||
|---|---|---|---|---|---|---|
| N = 22 | N = 22 | N = 24 | ||||
| HbA1c (%) | 3M-0M | 0.22 ± 0.93 | −0.35 ± 0.74 | 0.0321 | 0.07 ± 0.67 | 0.5509 |
| 6M-0M | 0.22 ± 0.87 | −0.39 ± 0.80 | 0.0212 | 0.24 ± 0.93 | 0.9427 | |
| Insulin (mU/L) | 3M-0M | 8.00 ± 36.76 | −4.15 ± 17.86 | 0.1731 | 4.45 ± 21.24 | 0.6944 |
| 6M-0M | 1.70 ± 9.08 | −3.14 ± 11.46 | 0.1282 | 16.25 ± 43.90 | 0.1249 | |
| HOMA-IR | 3M-0M | 0.14 ± 5.57 | −1.83 ± 8.01 | 0.3500 | 0.03 ± 9.27 | 0.9605 |
| 6M-0M | −0.12 ± 4.16 | −0.91 ± 5.82 | 0.6082 | 6.57 ± 19.17 | 0.1079 | |
| Glucose AC (mg/dl) | 3M-0M | −9.36 ± 45.86 | −1.36 ± 22.53 | 0.4683 | −11.20 ± 53.96 | 0.9038 |
| 6M-0M | −10.40 ± 53.00 | −0.32 ± 31.92 | 0.4515 | −9.38 ± 58.45 | 0.9525 | |
| LDL (mg/dl) | 3M-0M | 3.73 ± 24.30 | −8.18 ± 17.47 | 0.0690 | 8.58 ± 14.82 | 0.4239 |
| 6M-0M | −5.09 ± 25.13 | −4.50 ± 16.29 | 0.9267 | 1.79 ± 24.32 | 0.3505 | |
| HDL (mg/dl) | 3M-0M | 1.18 ± 7.58 | −1.45 ± 9.50 | 0.3145 | −0.25 ± 5.19 | 0.4552 |
| 6M-0M | −0.91 ± 9.73 | 0.32 ± 6.61 | 0.6272 | −1.67 ± 5.45 | 0.7497 | |
| TG (mg/dl) | 3M-0M | 2.68 ± 96.38 | −12.30 ± 81.99 | 0.5823 | 8.71 ± 55.45 | 0.7989 |
| 6M-0M | 22.18 ± 92.62 | −22.70 ± 68.88 | 0.0754 | 61.63 ± 213.90 | 0.4165 | |
| CHOL (mg/dl) | 3M-0M | 4.77 ± 23.97 | −9.86 ± 23.40 | 0.0467 | 9.04 ± 19.46 | 0.5091 |
| 6M-0M | −1.55 ± 25.34 | −4.45 ± 20.94 | 0.6802 | 8.17 ± 40.99 | 0.3355 | |
| FFA (mmol/L) | 3M-0M | −0.04 ± 0.50 | −0.28 ± 0.41 | 0.0935 | −0.13 ± 0.51 | 0.5287 |
| 6M-0M | 0.15 ± 0.61 | −0.15 ± 0.46 | 0.0712 | 0.02 ± 0.56 | 0.4540 | |
| SBP (mmHg) | 3M-0M | −0.09 ± 15.06 | −4.55 ± 14.00 | 0.3155 | −6.33 ± 14.96 | 0.1659 |
| 6M-0M | 1.95 ± 13.93 | −2.82 ± 11.03 | 0.2146 | −7.54 ± 13.77 | 0.0248 | |
| DBP (mmHg) | 3M-0M | −0.59 ± 9.59 | −2.77 ± 9.55 | 0.4537 | −3.33 ± 5.79 | 0.2537 |
| 6M-0M | 0.36 ± 8.28 | −0.91 ± 6.71 | 0.5783 | −3.17 ± 5.45 | 0.0921 | |
| pulse pressure (mmHg) | 3M-0M | 0.5 ± 11.08 | −1.77 ± 9.23 | 0.4641 | −3 ± 11.71 | 0.3034 |
| 6M-0M | 1.59 ± 11.68 | −1.91 ± 8.69 | 0.2664 | −4.38 ± 12.54 | 0.1019 | |
| mean pressure (mmHg) | 3M-0M | −0.42 ± 10.47 | −3.36 ± 10.35 | 0.3545 | −4.33 ± 8.16 | 0.1682 |
| 6M-0M | 0.89 ± 8.95 | −1.55 ± 7.34 | 0.3285 | −4.63 ± 6.94 | 0.0254 |
Abbreviations: HOMA-IR, homeostatic model assessment-insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; TG, triglycerides; CHOL, cholesterol; FFA, free fatty acid; SBP, systolic blood pressure; DBP, diastolic blood pressure; PP, pulse pressure; MBP, mean blood pressure.
aData were calculated by the value of later time point (3 month (3 M) or 6 month (6 M)) minus to starting point (0 M) and presented as mean ± SD.
bTwo sample t-test analysis was used to compare mean values between placebo and ADR-1 or ADR-3 groups.