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. 2018 Oct 17;596(22):5429–5441. doi: 10.1113/JP276502

Figure 3. Nicotinergic impact on anodal tDCS‐induced LTP‐like plasticity and its interaction with calcium channel blockade.

Figure 3

Standardized (to bl2/3) MEP amplitudes on the y‐axis plotted against the time points following anodal tDCS under NIC patch administration and different FLU dosages (2.5, 5 or 10 mg) and PLC, respectively. Under administration of NIC/PLC, tDCS‐induced excitability changes were completely abolished. NIC/FLU 5 restores facilitatory plasticity with significantly enhanced MEP amplitudes from 15–30 min after anodal tDCS compared to the respective baseline values. The MEPs of 2.5 and 10 mg of NIC/FLU were not different from the baseline value and the NIC/PLC condition. Filled symbols indicate statistically significant deviations of post‐stimulation MEPs from the respective baseline values. *Significant differences between the NIC/PLC and 5 mg of NIC/FLU conditions (Fisher's least significant difference, P < 0.05). Vertical bars indicate the 95% confidence interval. nm, next morning; ne, next evening.