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. 2018 Oct 13;596(22):5319–5341. doi: 10.1113/JP275437

Figure 1. Spontaneous contractile activity in the IAS and rectum and the effect of NOS and P2Y1 receptor blockade.

Figure 1

Sample traces showing contractile activity before and after NOS blockade with 100 μM l‐NNA (A) or P2Y1 receptor blockade with 1 μM MRS2500 (B) in the IAS (upper traces) and rectum (lower traces). C, bar graph summarizing the effects on contractile activity by blockade of one or both of these neural pathways. In both tissues, l‐NNA significantly (* P < 0.05) increased contractile activity (IAS, n = 16; rectum, n = 14) whereas MRS2500 (IAS, n = 5; rectum n = 5) did not (P > 0.05). The increase in contractile activity observed when both l‐NNA and MRS2500 (IAS, n = 5; rectum n = 9) were added together was not different (P > 0.05) from l‐NNA alone. Shown are mean values ± SD.