Skip to main content
. 2018 Oct 13;596(22):5319–5341. doi: 10.1113/JP275437

Figure 10. Comparison of the effect of apamin on spontaneous contractile activity in the IAS and rectum.

Figure 10

Sample traces showing the effect of apamin (1 μM) on contractile activity in the IAS (A) and rectum (B) in the absence (left traces) or presence (right traces) of blockers (l‐NNA 100 μM, TTX 1 μM, MRS2500 1 μM). Bar graphs at right summarize the effect of apamin on contractile activity ± blockers. Apamin had minimal effect upon contractile activity in the IAS in the absence (n = 5) or presence (n = 9) of blockers. In contrast, in rectum apamin approximately doubled contractile activity both in the absence (n = 6) and in the presence (n = 9) of blockers. These responses in rectum were significantly greater (P < 0.05) than in the IAS (*no blockers, &blockers). Shown are mean values ± SD.