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. 2018 Oct 13;596(22):5319–5341. doi: 10.1113/JP275437

Figure 12. Comparison of the effect of MRS2365 on spontaneous contractile activity in the IAS and rectum.

Figure 12

Sample traces show the changes in contractile activity following addition of MRS2365 (1 μM) to the IAS (A) and rectum (B) in the absence (left traces) and presence (right traces) of 1 μM MRS2500 (added at least 20 min before MRS2365) (l‐NNA 100 μM and TTX 1 μM present throughout). The dotted lines indicate zero active contraction. Bar graphs summarize the effect of MRS2365 on contractile activity in the IAS (A) and rectum (B) in the absence (n = 11, IAS; n = 13, rectum) and presence (n = 10, IAS; n = 6, rectum) of 1 μM MRS2500. MRS2365 contracted the IAS but reduced overall contractile activity in the rectum. Both effects were significantly reduced (* P < 0.05) by MRS2500. Shown are mean values ± SD.