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. 2018 Nov 14;8:16801. doi: 10.1038/s41598-018-34916-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AUCs for identified volumes of high (red), intermediate (blue) and low (black) risk for discriminating (left) Gleason Score 6 vs 7 and higher lesions and (right) Gleason Score 6 and 7 vs 8 and higher lesions in prostatectomy dataset (a), targeted biopsy dataset (b) and template biopsy dataset (c). In the prostatectomy dataset, the size of the high risk VOIs (threshold 900/800 µm²/s, PZ/TZ) was strongly predictive for high grade tumors (GS 6,7 vs GS ≥ 8, AUC = 0.952); the size of the intermediate risk VOIs (threshold 1100/850 µm²/s, PZ/TZ) was strongly predictive for intermediate grade tumors (GS 6 vs GS ≥ 7, AUC = 0.852); and the low risk VOIs (threshold 1300/1050 µm²/s, PZ/TZ) coincided with all tumor nodules in RP.