Table 3.

Performance of ADC volumes and PI-RADS in relationship to Gleason Score.

Radical prostatectomy	Specificity	Sensitivity	NPV	PPV	AUC
GS 6 vs GS 7–10
VOIHR*	1	0.63	0.722	1	0.8148
VOIIR**	1	0.704	0.765	1	0.8519
VOILR†	0.538	0.889	0.824	0.667	0.6652
GS 6–7 vs GS 8–10
VOIHR*	0.818	1	1	0.529	0.952
VOIIR**	0.818	1	1	0.529	0.9495
VOILR†	0.773	0.778	0.944	0.412	0.7992
Targeted Biopsies
GS 6 vs GS 7–10
VOIHR*	1	0.619	0.467	1	0.7619
VOIIR**	0.857	0.619	0.429	1	0.8636
VOILR†	0.714	0.714	0.455	0.882	0.6463
GS 6–7 vs GS 8–10
VOIHR*	0.818	1	1	0.6	0.8636
VOIIR**	0.727	1	1	0.5	0.8636
VOILR†	0.727	0.667	0.899	0.4	0.7121
PI-RADS (Targeted Biopsies)
GS 6 vs GS 7–10
PI-RADS 3–5	0.286	1	1	0.808	—
PI-RADS 4,5	0.429	0.905	0.6	0.826	—
GS 6–7 vs GS 8–10
PI-RADS 3–5	0.091	1	1	0.231	—
PI-RADS 4,5	0.227	1	1	0.261	—
Template Biopsies
GS 6 vs GS 7–10
VOIHR*	0.866	0.49	0.369	0.927	0.713
VOIIR**	0.743	0.673	0.433	0.866	0.716
VOILR†	0.914	0.404	0.34	0.933	0.663
GS 6–7 vs GS 8–10
VOIHR*	0.826	0.667	0.9	0.513	0.75
VOIIR**	0.844	0.667	0.902	0.541	0.774
VOILR†	0.826	0.667	0.9	0.513	0.74

Abbreviations: ADC = Apparent Diffusion Coefficient; AUC = Area under the curve; GS = Gleason Score; HR = High risk; IR = Intermediate risk; LR = Low risk; NPV = Negative Predictive Value; PPV = Positive Predictive Value; VOI = Volume of Interest.

^*ADC < 900 (Peripheral Zone); ADC < 800 (Transition Zone).

^**ADC < 1100 (Peripheral Zone); ADC < 850 (Transition Zone).

^†ADC < 1300 (Peripheral Zone); ADC < 1050 (Transition Zone).