Figure 1.
Cellular toxicity of statins is dependent on their lipophilicity. Four HNSCC cell lines were treated with either simvastatin or pravastatin for 96 hours and effect was determined by SRB assay. Data is presented as the percentage of cells unaffected by the drug relative to untreated control. (a) FaDu; (b) CaL-27; (c) Detroit 562; (d) UMSCC47. All graphs represent mean of at least three independent experiments carried out in triplicate.