Table 2.
Overall response rate (ORR) in dependence of AREG and EREG.
| ORR | p | ||
|---|---|---|---|
| AREG | |||
| All patients | low | 47.7 | 0.07 |
| high | 58.4 | ||
| DWT | low | 53.4 | 0.35 |
| high | 63.2 | ||
| RAS mut | low | 50.0 | 0.51 |
| high | 56.8 | ||
| BRAF mut | low | 27.8 | 0.73 |
| high | 35.3 | ||
| EREG | |||
| All patients | low | 50.0 | 0.36 |
| high | 56.0 | ||
| DWT | low | 58.6 | >0.99 |
| high | 57.9 | ||
| RAS mut | low | 53.4 | >0.99 |
| high | 53.3 | ||
| BRAF mut | low | 42.1 | 0.17 |
| high | 18.8 | ||
AREG, amphiregulin; EREG, epiregulin; high, ≥median expression level; low, <median expression level; ORR, overall response rate; p, two-sided Fisher's exact test p; DWT, double wild-type (RAS and BRAF wild-type.