Benzophenone 3 (BP-3) |
Zebrafish, Danio rerio
|
Obesity induction and alteration of circadian rhythms |
(57) |
Bisphenol A (BPA) |
3T3-L1 pre-adipocytes |
Adipocyte metabolic dysfunction and inflammation |
(53) |
|
Zebrafish |
Induction of TAG accumulation by up-regulation of ECS |
(64) |
|
HHL-5 cells |
Induction of TAG accumulation by up-regulation of ECS |
(64) |
|
Zebrafish |
Increased presence of hepatic lipid vacuoles, caused by alteration of the ECS |
(61) |
|
|
Increased TAG storage and FA synthesis, de novo lipogenesis and cholesterologenesis promotion |
(65) |
|
|
Evidence of the miRNome involvement in lipid synthesis, oxidation and related diseases |
(67) |
|
Seabream, Sparus aurata
|
Hepatic lipid accumulation associated to a decrease of lipid mobilization |
(70, 71) |
|
|
Alteration of hepatic structure lipids and TAG content and decreased phospholipids and glycogen abundance |
(75) |
|
Marine medaka, Oryzias javanicus
|
Upregulation of apo A-IV, apo A-I, Acsl1, Elovl, and fabp
|
(76) |
Brominated diphenyl ether 47 (BDE-47) |
3T3-L1 pre-adipocytes |
Increased levels of Pparɤ2, Cebpα, Cebpβ, Cebpɤ, Srebf1a, Lpl, Slc2a4, Fabp4, Adipoq, G6pc, Lep, and Igf1. Transgenerational study
|
(83) |
Cypermethrin (CYP), atrazine (ATZ), 17α-ethynyestradiol (EE2) |
C57BL/6J mice |
Alteration of the hepatic levels of PPARα, PPARɤ, and SREBP1C |
(52) |
Dibutyltin (DBT) |
Human MSCs |
C/EBPα, PPARγ2, FABP4, FSP27, LPL upregulation |
(44) |
Dichlorodiphenyltrichloroethane (DDT) |
Hsd:Sprague Dawley®™SD®™ Harlan |
Obesity induction in males. Transgenerational study
|
(78) |
Di(2-ethylhexyl) phthalate (DEHP) |
HepG2 cells |
Activation of the SREBP-1c and PPARα-signaling pathway |
(49) |
|
Zebrafish |
Alteration of FOXA2 and FOXA3 transcription factor networks', “Metabolic pathways,” “metabolism of amino acids and derivatives,” “metabolism of lipids and lipoproteins,” and “fatty acid, triacylglycerol, and ketone body metabolism” |
(56) |
|
|
Up-regulation of hepatic PPARα, Cb1, and SREBP levels, de novo FA synthesis and hepatic steatosis |
(63) |
|
Sprague-Dawley rats |
Hepatic steatosis, associated to inflammation, lipid peroxidation, oedema of the liver cells and hepatic damage |
(48) |
Di-isodecyl- phthalate (DiDP) |
Seabream |
PPAR-mediated regulation of fabp
|
(74) |
DiNP |
Zebrafish |
Upregulation of orexigenic and hepatosteatosis signals, deregulation of the peripheral and central ECS and lipid metabolism |
(62) |
DiNP |
Seabream |
Alteration of hepatic structure lipids and triglycerides content and decreased phospholipids and glycogen abundance |
(75) |
Diethylene glycol dibenzoate (DGB) |
Zebrafish |
Increase of de novo lipogenesis, cholesterol esters, TAG production and potential conversion of lipids into apolipoprotein particles |
(65) |
|
Seabream |
PPARα agonist, stimulation of key lipolytic genes and downregulation of ECS |
(73) |
Methoxychlor |
Sprague-Dawley rats |
Obesity induction in females. Transgenerational study
|
(85) |
BPA, DEHP and dibutylphthalate (DBP) mixture |
Sprague-Dawley rats |
Obesity induction. Transgenerational study |
(86) |
Nonylphenol (NP) |
Sprague-Dawley rats |
Hepatic srebp-1C, fas and ucp2 upregulation
|
(46) |
|
Wistar rats |
Obesity induction, increased levels of cholesterol and leptin and alteration of the expression of genes involved in lipogenesis and adipogenesis. Transgenerational study
|
(87, 88) |
|
Seabream |
Hepatosteatosis, alteration of lipid metabolism |
(69, 71) |
BPA, NP, tert-octylphenol (t-OP) Mixture |
Seabream |
Alteration of lipid metabolism |
(72) |
Polycyclic aromatic hydrocarbon (PAH) mixture |
BALB/cByj mice |
Increased Pparɤ, Cox2, and Cebpα expression in adipose tissue. Transgenerational study
|
(84) |
RXR-specific ligands LG100268 and AGN195203 |
African clawed frog, Xenopus laevis
|
Ectopic adipocyte formation around the gonads |
(43) |
Tributyltin (TBT) |
murine 3T3-L1 adipocytes |
RXR-PPARɤ-mediated pro-adipogenesis in liver and adipose tissue |
(40, 41, 42) |
|
|
Increase the number of differentiated adipocites. Transgenerational study
|
(82) |
|
C57BL/6 mice |
Lipid accumulation in adipose tissues and onset of hepatic steatosis |
(43) |
|
|
Increased lipid accumulation in differentiated adipocytes associated to an increase of early adipogenesis markers, Pparɤ and Fapb4. Transgenerational study
|
(82) |
|
African clawed frog |
Activation of RXR/PPARɤ pathways |
(43) |
|
Zebrafish |
Male: increased body weight, hepatosomatic index, hepatic TAG abundance and expression of adipogenesis and lipogenesis genes pparγ, srebp1, fasn, 11β-hsd2, c/ebpβ, and dgat2 Female: hepatomegaly with lack of response of signals involved in adipogenesis |
(54) |
|
|
Obesity induction and alteration of circadian rhythms |
(57) |
|
Trout (Oncorhynchus mykiss) Primary adipocyte culture |
Promotion of adipocytes differentiation by enhancing PPARγ and C/EBPα protein expression |
(60) |
2,3,7,8-Tetrachlorodibenzodioxin (TCDD) |
C57BL/6J mice |
Sex specific modulation of mRNA levels involved in adipose tissue and hepatic metabolism, inflammation, xenobiotic metabolism and endocrine disruption |
(50) |
|
|
AHR mediates obesity and fatty liver onset |
(51) |
Tetrabrominated bisphenol A (TBBPA) |
Zebrafish |
Obesity induction and alteration of circadian rhythms |
(57) |
t-OP |
Seabream |
Hepatosteatosis, alteration of lipid metabolism |
(69, 71) |
Triclosan (TCS) |
Zebrafish |
Upstream regulation of miR-125b |
(68) |
|
Human MSCs |
decreasing aP2, lpl, and adipoq gene expression |
(47) |
|
Zebrafish |
impaired mRNA expression levels of β-oxidation transcripts and lipid β-oxidation genes, including pparα, cpt1, lpbe, cyp4a10, and aco
|
(55) |
Tyhriphenyltin (TPT) |
Trout Primary adipocite culture |
Promotion of adipocytes differentiation by enhancing PPARγ and C/EBPα protein expression |
(60) |
tris (1,3-dichloroisopropyl) phosphate (TDCIPP) |
Zebrafish |
Obesity induction and alteration of circadian rhythms |
(57) |