Fig. 4. The IH staining pattern of CDC6 differs between BPH and PCa tissues (200× magnification). (A) Weak cytoplasmic staining intensity of CDC6 in BPH epithelial tissue. Note the intense staining in stromal muscle cells. (B) Moderate staining intensity of CDC6 in localized PCa with a Gleason score of 7 (3 + 4). (C) Strong staining intensity of CDC6 in advanced PCa with a Gleason score of 8 (4 + 4).

CDC6 = cell devision cycle 6, BPH = benign prostatic hyperplasia, PCa = prostate cancer.