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. 2018 Nov 8;9:2464. doi: 10.3389/fimmu.2018.02464

Figure 2.

Figure 2

Immunogenicity of recombinant ZIKV E protein in cynomolgus macaques. Animals were given 25 μg ZIKV E protein with CoVaccine HT™ as an adjuvant at day 0 and 21. The control group received unrelated glycoproteins at day 0 and PBS at day 21. Blood was collected at various points throughout the vaccination schedule. Individual animal's ZIKV E specific IgG MFI of serum from the vaccinated and control groups are depicted. The negative assay cutoff is shown by the dotted line. It was calculated by taking the mean value of the pre-vaccination samples (day 0) of all 8 animals and adding 3 standard deviations. Vaccinated animals had significantly higher ZIKV E specific IgG titers as compared to controls at days 21, 35, and 49 (*p < 0.05, **p < 0.01).