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. 2018 Aug 1;12(2):67–84. doi: 10.5005/jp-journals-10008-1248

Table 2A: Baseline demographics of included trials

Study    Country    Single center or multicenter    Study design    2016 journal 2-year cites per document    Number of eyes    Age    Number of males    Number of Caucasians    Mean cup-to-disk ratio    Mean visual field (MD, dB)   
Samuelson et al., 2011    United States    Multicenter    Prospective randomized controlled trial    Ophthalmology; 7.40    117    74 ±8    46    83    n/a    –3.75 ± 3.03   
Fea etal., 2014    Europe    Multicenter    Prospective randomized controlled trial    Clinical ophthalmology; 1.86    94    64.5 ± 10.3    37    94    n/a    n/a   
Buchacra et al., 2011    Spain    Single center    Prospective case series    Clinical ophthalmology; 1.86    10    54.4 ±7.9    9    n/a    n/a    n/a   
Ahmed etal., 2014    Armenia    Single center    Prospective case series    Journal of Cataract and Refractive Surgery; 2.69    39    62.8 ± 12.6    21    39    0.7 ±0.1    –6.47 ± 7.2   
Voskanyan et al., 2014    Europe    Multicenter    Prospective case series    Advances in therapy; 2.98    99    66.4 ± 10.9    43    95    0.7 ±0.2    n/a   
Vandewalle et al., 2009    Belgium    Single center    Prospective case series    Bulletin de la Societe Beige d’Ophtalm ologie; 0.158 (2015)    10    69    n/a    n/a    n/a    –13.7   
Fea, 2010    Italy    Single center    Prospective randomized controlled trial    Journal of Cataract and Refractive Surgery; 2.69    12    64.5 ±3.4    4    n/a    n/a    n/a   
Belovay etal., 2012    Canada    Single center    Prospective case series    Journal of Cataract and Refractive Surgery; 2.69    26    78.8 ± 7    7    18    0.76 ±0.16    –12.6 ±7.1   
2nd study arm    Canada    Single center    Prospective case series    Journal of Cataract and Refractive Surgery; 2.69    23    75 ± 7.3    9    11    0.71 ±0.17    .-10.2 ±8.1   
Patel etal., 2013    United Kingdom    Single center    Prospective case series    Clinical and Experimental Ophthalmology; 2.93    44    76.8    n/a    n/a    n/a    n/a   
Arriola- Villalobos et al., 2012)    Spain    Single center    Prospective case series    British Journal of Ophthalmology; 3.52    19    74.63 ± 8.44    9    19    n/a    n/a   
Arriola-Villalobos et al., 2013    Spain    Single center    Prospective case series    British Journal of Ophthalmology; 3.52    20    75.1 ± 8.6    9    20    n/a    n/a   
Fernandez-Barrientos et al., 2010    Spain    Single center    Prospective randomized controlled trial    Investigative Ophthalmology and Visual Science; 3.15    17    75.2 ±7.2    6    n/a    n/a    n/a   
Spiegel etal., 2009    Europe    Multicenter    Prospective case series    European Journal of Ophthalmology; 1.15    47    76.2 ±6.7    18    46    n/a    n/a   
Wang etal., 2015    Canada    Single center    Retrospective case series    Journal of Ophthalmology; 1.79    96    70.6 ±2.8    53    86    n/a    –7.3 ±2.1   
Klamann etal., 2015    Germany    Single center    Retrospective case series    Graefe’s Archive for Clinical and Experimental Ophthalmology; 2.42    35    61.3 ±3.5    15    n/a    n/a    n/a   
Khan etal., 2015    Canada and United States    Multicenter    Retrospective case series    Journal of Cataract and Refractive Surgery; 2.69    49    77.5 ±11.9    20    34    n/a    –11.5 ±8.0   
Seibold etal., 2016    United States    Single center    Retrospective case series    Journal of Cataract and Refractive Surgery; 2.69    64    73.9 ±8.8    23    34    n/a    n/a   
Gallardo etal., 2016    United States    Single center    Retrospective case series    Clinical Ophthalmology; 1.86    100    74.6 ±8.9    37    14    0.7 ±0.2    n/a   
Ferguson et al., 2016    United States    Single center    Retrospective case series    Clinical Ophthalmology; 1.86    350    74.1 ± 9.0    133    n/a    n/a    n/a   
Lindstrom et al., 2016    Armenia    Single center    Prospective case series    Advances in Therapy; 2.98    57    65.3 ±9.0    30    57    0.7 ±0.1    –4.9 ±5.3   
El Wardani etal., 2015    Switzerland    n/a    Retrospective case series    Klinische Monatsblatter fur Augenheilkunde; 0.52    31    n/a    n/a    n/a    n/a    n/a   
2nd Study Arm    Switzerland    n/a    Retrospective case series    Klinische Monatsblatter fur Augenheilkunde; 0.52    22    n/a    n/a    n/a    n/a    n/a   
Katzetal., 2015    Armenia    Single center    Prospective randomized controlled trial    Clinical Ophthalmology; 1.86    38    68.1 ± 9.1    27    38    0.68 ±0.11    –4.72 ± 4.42   
2nd Study Arm    Armenia    Single center    Prospective randomized controlled trial    Clinical Ophthalmology; 1.86    41    67.8 ±9.3    19    41    0.71 ±0.14    –5.20 ± 5.65   
3rd Study Arm    Armenia    Single center    Prospective randomized controlled trial    Clinical Ophthalmology; 1.86    40    60.9 ±8.1    19    40    0.70 ±0.12    –4.81 ± 4.22   
Shiba etal., 2017    Japan    Single center    Prospective case series    Journal of Ophthalmology; 1.79    10    64.6 ± 10.7    7    0    n/a    –15.4 ±8.1   
Zheng etal., 2017    USA    Single center    Retrospective case series    International Journal of Ophthalmology; 1.30    34    74    9 of 30    21 of 30    n/a    n/a   
Berdahl etal., 2017    Armenia    Single center    Prospective case series    Clinical & Experimental Ophthalmology; 2.93    53    64.7 ±9.6    27    53    0.7 ±0.1    n/a   
Ferguson et al., 2017    USA    Single center    Retrospective case series    Journal of Cataract and Refractive Surgery; 2.69    115    77.42 ±8.51    86    n/a    0.68 ±0.11    n/a   
Gonnermann et al., 2017    Germany    Single center    Retrospective case series    Graefe’s Archivefor Clinical and Experimental Ophthalmology; 2.42    27    73.8 ±7.8    13    27    n/a    n/a   
Kurji etal., 2017    Canada    Single center    Retrospective case series    Canadian Journal of Ophthalmology; 1.57    34    75.02 ± 10.34    11    n/a    n/a    n/a   

*MD = Mean deviation; dB = Decibels; n/a = Not available.