Table 5B: Efficacy outcomes of one versus three first generation iStent implantation

		One iStent						Three iStents						Meta-Analysis
Outcome		Mean		Standard deviation		Number of eyes		Mean		Standard deviation		Number of eyes		Weighted mean difference		95%CI –Lower bound		95%CI –Upper bound		p-value
IOP reduction Preoperative		4.67		2.18		999		9.33		6.23		63		–4.66		–6.20		–3.12		p <0.001
IOP Postoperative		19.72		3.06		867		22.52		4.50		63		–2.80		–3.93		–1.67		p <0.001
IOP Reduction in		14.80		1.25		882		13.23		1.80		63		1.57		1.12		2.02		p <0.001
medications Preoperative		0.97		0.46		999		1.74		0.53		63		–0.77		–0.90		–0.64		p <0.001
medications		1.62		0.48		999		1.94		0.75		63		–0.32		–0.51		–0.13		p <0.001
Postoperative medications		0.67		0.34		999		0.21		0.22		63		0.46		0.40		0.52		p <0.001

*IOP = Intraocular pressure. CI = Confidence interval. n/a = Not available. Note: red text denotes endpoints that substantially differed from those of the original analysis.