Table 3.
TOP down-regulated and hyper-methylated genes in treatment-naïve ulcerative colitis [UC]
| Gene symbol | % methyl | p < 0.05 | #c | p < 0.05 | Log2fc > 1.5 |
|---|---|---|---|---|---|
| methyl | transcript | transcript | |||
| ADIRF | -5,72 | 0,004 | 36 | 4,34E-18 | -1,88 |
| AGMO | -10,86 | 0,022 | 7 | 9,44E-09 | -1,57 |
| ALPI | -3,05 | 0,0102 | 34 | 1,10E-14 | -1,91 |
| ANKRD62 | -0,19 | 0,0011 | 91 | 2,47E-14 | -2,25 |
| BCHE | -4,17 | 0,0442 | 10 | 4,86E-12 | -1,69 |
| BRINP3 | -0,22 | 0,0407 | 29 | 6,76E-11 | -1,74 |
| CLDN8 | -0,45 | 0,0005 | 8 | 2,17E-05 | -1,9 |
| CYP3A4 | -15,45 | 0,0009 | 2 | 3,87E-21 | -3,58 |
| DEFB1 | -7,09 | 0,0334 | 16 | 2,16E-11 | -1,94 |
| FABP1 | -16,56 | 1,52E-05 | 18 | 1,36E-07 | -1,66 |
| FAM151A | -3,59 | 0,0091 | 16 | 4,28E-12 | -1,59 |
| FRMD1 | -2,58 | 0,0076 | 109 | 4,49E-14 | -2,26 |
| GBA3 | -14,5 | 0,0033 | 7 | 1,15E-07 | -1,98 |
| GUCA2A | -12,84 | 0,0134 | 18 | 8,25E-10 | -2,26 |
| GUCA2B | -3,08 | 0,0345 | 41 | 2,67E-08 | -2,18 |
| HAVCR1 | -12,55 | 3,60E-05 | 6 | 4,58E-12 | -2,28 |
| HMGCS2 | -13,13 | 6,56E-05 | 18 | 2,91E-08 | -2,41 |
| HSD17B2 | -2,69 | 0,0456 | 15 | 1,71E-23 | -2,11 |
| MEP1A | -11,49 | 0,009 | 18 | 1,76E-16 | -2,15 |
| OTC | -6,32 | 0,0359 | 28 | 7,09E-10 | -1,68 |
| PCK1 | -6,73 | 0,0212 | 18 | 1,52E-07 | -2,18 |
| PNLIPRP2 | -15,2 | 5,99E-05 | 23 | 1,63E-05 | -1,74 |
| PRAP1 | -1,32 | 0,0025 | 260 | 1,97E-09 | -2,49 |
| SLC17A8 | -2,89 | 0,0082 | 45 | 2,95E-06 | -1,6 |
| SLC22A4 | -0,35 | 0,0174 | 172 | 1,25E-27 | -1,72 |
| SLC25A34 | -12,01 | 0,0099 | 40 | 2,17E-15 | -1,76 |
| SLC30A10 | -7,67 | 0,0006 | 14 | 4,89E-10 | -1,89 |
| SLC3A1 | -15.79 | 0,0002 | 10 | 1,29E-17 | -2,43 |
| SLC6A19 | -12,17 | 0,0057 | 68 | 1,53E-09 | -2,82 |
| SULT1A2 | -11,71 | 0,003 | 13 | 7,56E-09 | -1,67 |
| TINCR | -0,66 | 0,0107 | 72 | 1,58E-12 | -1,98 |
| TMIGD1 | -9,19 | 0,0135 | 6 | 1,16E-09 | -2,32 |
| UGT1A10 | -8,16 | 0,0005 | 34 | 4,04E-15 | -1,79 |
| UGT1A8 | -5,96 | 0,0091 | 23 | 1,67E-10 | -1,85 |
#c indicates number of methylated cytosines. % methyl indicates % difference of DNA methylation normal [N]-UC.