Figure 3.

Differential expression of circRNAs in CUMS mice by SLPN treatment. (a) Volcano plot of circRNAs expression in CUMS mouse VMPC tissue. X‐asis: Log2 ratio of circRNA expression levels. Y‐asis: the FDR value (−log10 transformed) of circRNA. (b) Number of differentially expressed circRNAs in VMPC tissues among different chromosomes. Green and red columns represent numbers of down‐regulated and up‐regulated circRNAs respectively. (c) Volcano plot of circRNAs expression in hippocampus tissue of CUMS mice. (d) Number of differentially expressed circRNAs in hippocampus tissues among different chromosomes. (e) Heat map showing the differentially expressed circRNAs in mouse VMPC and hippocampus tissues. VMPC: ventral medial prefrontal cortex; CUMS: chronic unpredictable mild stresse; SLPN: total saponins from the leaves of Panax notoginseng