Table II.
Disease | dbSNP ID | Genes | Function | Genotype | Refs. |
---|---|---|---|---|---|
SLE, AS, CD | rs2476601 | PTPN22 | T-cell signaling; macrophage polarization; interferon signaling | TT | (7) |
AS, CD | rs27434 | ERAP1 | Antigen presentation | CT | (9) |
AS, CD | rs30187 | ERAP1 | Antigen presentation | AG | (10) |
SLE, AS, CD | rs602662 | FUT2 | A and B antigen synthesis pathway | AG | (10,11) |
SLE, CAD | rs11556218 | IL16 | Chemoattractant; modulator of T-cell activation | GT | (12,13) |
CD | rs10781499 | CARD9 | Activation of pro- and anti-inflammatory cytokines | CT | (10,11) |
CD | rs4077515 | CARD9 | Activation of pro- and anti-inflammatory cytokines | AG | (10,11) |
CD | rs3197999 | MST1 | Regulation of cell apoptosis | CT | (11) |
BC | rs10936599 | MYNN | Control of gene expression | CT | (12,14) |
Bronchial asthma | rs6967330 | CDHR3 | Calcium ion binding | AA | (13) |
SLE, systemic lupus erythematosus; AS, ankylosing spondylitis; CD, Crohn's disease; CAD, cardiovascular disease; BC, bladder cancer.