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. 2018 Oct 4;18(6):5058–5068. doi: 10.3892/mmr.2018.9534

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — lncRNA and mRNA correlation analysis revealed potential connections between them. Hierarchically clustered heat map of (A) mRNA and (B) lncRNA with fold-changes no less than 2.0 between db/db and db/m mice. The vertical axis represents each mRNA or lncRNA and the horizontal axis represents different groups. (C) Interaction network of lncRNA and mRNA were constructed using Pearson Coefficients (P≤0.001). (D) Interaction network of SOX2OT and its associated genes were constructed using the same method. Circles denote lncRNA and rectangles denote mRNA. Red is enriched in the db/db group and green is enriched in the db/m group. Red edges denote positive interactions and green edges denote negative interactions. Lnc, long noncoding; SOX2OT, SOX2-original transcript; db/db, Leprdb/Leprdb.