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miR-146a mimic inhibits LPS-inducible cytokine production on osteoclastogenesis in Raw264.7 cells. Cells were treated with 30 ng/ml RANKL, 100 ng/ml LPS and 200 nM NC mimic or miR-146a mimic for 72 h. Total RNA was extracted to detect IL-1β, IL-6 and TNF-α expression. Bars represent the mean ± standard error of the mean. *P<0.05 and **P<0.01. miR, microRNA; LPS, lipopolysaccharide; NC, negative control; IL, interleukin; TNF-α, tumor necrosis factor-α.
