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. 2018 Oct 10;18(6):4821–4830. doi: 10.3892/mmr.2018.9544

Figure 1.

Figure 1.

Figure 1.

Pretreatment with formononetin reduces myocardial tissues injury, improves cardiac function and decreases apoptosis in heart tissue from aged mice. (A) Infarct size was measured using triphenyltetrazolium chloride staining to distinguish necrotic from viable myocardium. White zones indicate infarcted sections. (B) Infarct size (expressed as the percentage risk zone of the total left ventricle). The effects of various interventions on hemodynamic parameters in the isolated aged mice hearts were assessed: (C) left ventricular end systolic diameter; (D) left ventricular end diastolic diameter; (E) fractional shortening; and (F) ejection fraction. The data are from four independent experiments. *P<0.05, **P<0.01 and ***P<0.001. I/R, ischemia/reperfusion; Form, treated with formononetin; PC, preconditioning.