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. 2018 Sep 26;18(6):4886–4894. doi: 10.3892/mmr.2018.9511

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — BRCC3 interference suppresses EMT and the Snai pathway in cervical cancer cells. (A) mRNA expression levels of EMT-associated factors (E-cadherin, Vimentin, MMP-2 and MMP-9) were investigated via RT-qPCR in HeLa and SiHa cervical cancer cells following BRCC3 interference. Expression levels of proteins associated with EMT in HeLa and SiHa cervical cancer cells were investigated by (B) western blot analysis and (C) quantification. (D) mRNA expression levels of Snai1 and Snai2 were investigated by RT-qPCR in HeLa and SiHa cervical cancer cells following BRCC3 interference. Snai1 and Snai2 protein expression levels in HeLa and SiHa cervical cancer cells were investigated via (E) western blotting and (F) quantification. **P<0.01 vs. respective NC group. BRCC3, breast cancer type 1 susceptibility protein/breast cancer type 2 susceptibility protein-containing complex subunit 3; si, small interfering; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; NC, negative control; EMT, epithelial-mesenchymal transition; Snai, snail family transcriptional repressor; MMP, matrix metalloproteinase.