Table IV.
Multivariate analysis results of overall survival and disease-free survival in 113 patients with hepatocellular carcinoma.
| Overall survival | Disease-free survival | |||
|---|---|---|---|---|
| Prognostic factor | HR (95% CI) | Pa | HR (95% CI) | Pa |
| CYP4F2 expression | 0.872 (0.794–0.958) | 0.004 | 0.948 (0.896–1.003) | 0.064 |
| Age at operation | 1.028 (0.987–1.071) | 0.188 | 0.995 (0.970–1.019) | 0.667 |
| Sex | ||||
| Male | 1 (reference) | 1 (reference) | ||
| Female | 0.886 (0.314–2.504) | 0.820 | 1.205 (0.664–2.189) | 0.540 |
| HBV or HCV | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 0.936 (0.395–2.216) | 0.880 | 1.106 (0.601–2.037) | 0.746 |
| Cirrhosis | ||||
| No | 1 (reference) | 1 (reference) | ||
| Yes | 1.969 (0.747–5.196) | 0.171 | 2.139 (1.144–3.999) | 0.017 |
| Histologic grade | 0.009 | |||
| 1 (well) | 1 (reference) | 1 (reference) | ||
| 2 (moderate) | 1.145 (0.371–3.529) | 0.814 | 1.297 (0.599–2.810) | 0.509 |
| 3 (poorly) | 3.856 (1.201–12.380) | 0.023 | 2.940 (1.232–7.016) | 0.015 |
| 4 (undifferentiated) | NA. | NA. | NA. | NA. |
| Pathologic stage | 0.074 | 0.113 | ||
| I | 1 (reference) | 1 (reference) | ||
| II | 0.783 (0.331–1.854) | 0.578 | 1.112 (0.624–1.984) | 0.719 |
| III | 2.808 (0.944–8.355) | 0.064 | 2.734 (1.167–6.400) | 0.021 |
| IV | 1.916 (0.210–17.457) | 0.564 | 3.210 (0.379–27.193) | 0.285 |
a
Multivariate Cox regression analysis. HR, hazard ratio; CI, confidence interval; HBV, hepatitis B viral infection; HCV, hepatitis C viral infection.