Contents
1	The Pharmacology of Muscarinic Receptors
1.1	Introduction
1.2	Muscarinic receptor subtypes
2	Pharmacological Effects of Agonists and Therapeutic Applications
2.1	Cardiovascular system
2.2	Gastointestinal tract
2.3	Other smooth muscle
2.4	Glandular secretions
2.5	The eye
2.6	Central nervous system
3	Pharmacological Effects of Antagonists and Therapeutic Applications
3.1	Introduction
3.2	Cardiovascular system
3.3	Gastrointestinal tract
3.4	Urinary bladder
3.5	Airways
3.6	The eye
3.7	Prostate gland
4	The Medicinal Chemistry of Muscarinic Receptor Agonists and Antagonists
4.1	Scope
5	Muscarinic Agonists
5.1	Arecoline
5.2	Heterocyclic and other derivatives of arecoline
5.3	The synthesis of 1-aza-bicyclo[2.2.1]heptanes (1-azanorbornanes) and 1-azabicyclo[2.2.2]octanes (quinuclidines)
5.3.1	Intramolecular nucleophilic displacement by amines
5.3.2	Dieckmann condensation
5.3.3	Ester surrogates
6	Muscarinic Antagonists
6.1	Enantioselective synthesis of tertiary centres; tolterodine, rociverine, IQNP
6.2	Diels-Alder reactions
6.2.1	Indole alkaloids; allosteric activators of muscarinic binding
6.2.2	Himbacine; a muscarinic antagonist with allosteric properties
6.2.3	Cyclostellettamines; macrocyclic muscarinic antagonists
7	Conclusions and Future Prospects
8	References