| Peptide | IC50 | |||||||
| hY1 [nM] |
IC50 (Pep)
IC50 (NPY) |
hY2
[nM] |
IC50 (Pep)
IC50 (NPY) |
hY4
[nM] |
IC50 (Pep) IC50 (NPY) | hY5
[nM] |
IC50 (Pep)
IC50 (NPY) |
|
| pNPY | 0.23 | (1) | 0.04 | (1) | 5.5 | (1) | 0.8 | (1) |
| [A1]-pNPY | 21 | (91) | 0.2 | (5) | 5.8 | (1.1) | 2.2 | (2.8) |
| [A2]-pNPY | 114 | (496) | 0.3 | (8) | 7.8 | (1.4) | 5.5 | (7) |
| [A5]-pNPY | 228 | (991) | 24 | (600) | 25 | (4.5) | 32 | (40) |
| [A8]-pNPY | 32 | (139) | 0.7 | (18) | 60 | (11) | 55 | (69) |
| [A11]-pNPY | 8.0 | (35) | 0.2 | (5) | 3.1 | (0.6) | 0.5 | (0.6) |
| [A13]-pNPY | 7.5 | (33) | 0.1 | (3) | 37 | (6.7) | 17 | (21) |
| [A19]-pNPY | 282 | (1226) | 1.6 | (40) | 4.1 | (0.7) | 1.4 | (1.8) |
| [A20]-pNPY | 71 | (309) | 1.2 | (30) | 161 | (29) | 19 | (24) |
| [A21]-pNPY | 5.5 | (24) | 0.2 | (5) | 66 | (12) | 32 | (40) |
| [A25]-pNPY | 11 | (48) | 0.7 | (18) | 201 | (37) | 80 | (100) |
| [A27]-pNPY | 250 | (1087) | 1.4 | (35) | 340 | (62) | 370 | (463) |
| [A32]-pNPY | 723 | (3143) | 45 | (1125) | 380 | (69) | 7.7 | (9.5) |
| [A33]-pNPY | >1000 | (>4348) | 54 | (1350) | >1000 | (>182) | 94 | (118) |
| [A34]-pNPY | 94 | (409) | 6.0 | (150) | 7.4 | (1.3) | 1.3 | (1.6) |
| [A35]-pNPY | >1000 | (>4348) | >1000 | (>25000) | >1000 | (>182) | >1000 | (>1250) |
| [A36]-pNPY | 970 | (4217) | 48 | (1200) | 141 | (26) | 68 | (85) |
| [L34]-pNPY | 0.3 | (0.05) | 1.8 | (2.3) | ||||
| [D-P34]-pNPY | 266 | (1157) | 271 | (49) | 156 | (195) | ||
| [Ahx5-24]-NPY | >1000 | (>4348) | 1.4 | (35) | 600 | (109) | 795 | (994) |
| [Ahx5-24, P34]-NPY | >1000 | (>4348) | 514 | (93) | >10000 | (>12500) | ||
| [Ahx8-20]-NPY | 28 | (122) | 67 | (12) | 31 | (39) | ||
| [Ahx8-19]-NPY | 46 | (200) | 95 | (17) | 19 | (24) | ||
| [Ahx9-20]-NPY | 74 | (322) | 108 | (20) | 29 | (36) | ||
| [Ahx9-17]-NPY | 13 | (57) | 45 | (8) | 11 | (14) | ||
| hPP | >1000 | (>4348) | >1000 | (>25000) | 0.04 | (0.007) | 24 | (30) |
| [Ahx5-24]-hPP | >500 | (>2174) | >1000 | (>25000) | 144 | (26) | >1000 | (>1250) |
| [Ahx5-20]-hPP | >1500 | (>6522) | >1000 | (>25000) | 216 | (39) | >7000 | (>8750) |
| [Y5-20]-hPP | >500 | (>2174) | >1000 | (>25000) | 27 | (5) | >5000 | (>6250) |