Table 1.
Examples of animal models of pre- and perinatal stress and human analogs.
| Name | Description | Human Analog |
|---|---|---|
| Prenatal substance exposure | Injection of substance (e.g., cocaine, morphine) into mother | Prenatal substance exposure |
| Synthetic GC exposure | Injection of synthetic glucocorticoid into mother | Glucocorticoid use during pregnancy |
| Food restriction paradigm | Restrict mother access to food | Malnutrition |
| Restraint and immobilization stress paradigm | Mother kept in cylindrical tube or restrained with adhesive tape | Prenatal anxiety |
| Immune activation | synthetic double strand RNA polyriboinosinic-polyribocytidilic acid (poly I:C) administered into mother | Prenatal viral infection |
| Maternal separation | Offspring exposed to maternal absence during first postnatal weeks | Postnatal neglect |