Table 2.
Patient disposition and prior treatment history.
| Phase Ib (n = 10) |
Phase II (n = 9) |
Total (n = 19) |
|
|---|---|---|---|
| Off treatment reason | |||
| Disease progression | 9 | 6 | 15 |
| • CNS | 6 | 5 | 11 |
| • Extra-CNS | 2 | 1 | 3 |
| • Both | 1 | 0 | 1 |
| Consent withdrawal | 0 | 2 | 2 |
| Noncompliance | 1 | 1 | 2 |
| Prior treatment history | |||
| Prior lapatinib/capecitabine | |||
| • Lapatinib (no capecitabine) | 1 | 2 | 3 |
| • Capecitabine (no lapatinib) | 2 | 0 | 2 |
| • Both | 5 | 4 | 9 |
| Prior CNS radiation/surgery | |||
| • Rad only (SRS/WB/both) | (0/3/1) | (1/1/3) | 9 |
| • Surgery only (no radiation) | 0 | 0 | 0 |
| • Both radiation and surgery (SRS/WB/both) | (1/1/1) | (0/0/0) | 3 |
CNS, central nervous system; SRS, stereotactic radio surgery; WB, whole brain.