Table 5.
Results of a linear mixed regression model for log endotoxin release (log of EU/mL) by Escherichia coli after exposure to cefalotin (CF) or ceftazidime (CAZ).
| Parameter | Estimate | SEM | P-value |
|---|---|---|---|
| Parent isolates (Ref.) ∗ | 6.07 | 0.11 | <0.001 |
| CAZ | 0.50 | 5.01 x 10−3 | <0.001 |
| CF | 0.02 | 5.01 x 10−3 | 0.699 |
| Interactions† | |||
| CAZ x generation | 3.78 x 10−4 | 5.23 x 10−3 | 0.942 |
| CF x generation | 1.39 x 10−3 | 5.23 x 10−3 | 0.791 |
| Time (h) | 1.60 | 0.02 | <0.001 |
| Time2 (h2) | -0.16 | 5.39 x 10−3 | <0.001 |
| Time3 (h3) | 0.01 | 3.54 x 10−4 | <0.001 |
|
| |||
| Between-replicate variance | 0.03 | 0.16 | |
Endotoxin release was measured at various time points (2, 4, 6, 8, and 10 h) and resistance was induced over varying numbers of generations.
∗Baseline to which other samples were compared was a parent isolate (generation 0)
†Interactions were not created with the parent isolate as there was only 1 generation