(b) Major morbidity

Variables	Univariate			Multivariate
	OR	95% CI	p	OR	95% CI	p
Age	1.036	1.010–1.062	0.006	1.050	1.020–1.083	0.001
Gender	1.148	0.669–1.969	0.617
BMI (kg/m2)	1.011	0.944–1.083	0.758
ASA score	1.329	0.752–2.346	0.328
Indication of extended hepatectomy
Benign liver disease	Reference	Reference	Reference	Reference	Reference	Reference
Primary malignancy	2.017	0.497–8.187	0.326	1.347	0.195–9.291	0.762
Metastatic disease	3.331	1.827–6.072	<0.001	2.387	1.111–5.127	0.026
Preoperative chemotherapy	0.626	0.274–1.428	0.266
Platelet count <150 x 109/L	10.427	2.321–46.845	0.002	4.923	0.922–26.296	0.062
Intraoperative blood loss (L)	1.365	1.181–1.577	<0.001	1.309	0.863–1.985	0.206
Intraoperative RBC/FFP transfusion	2.880	1.555–5.336	0.001	1.285	0.491–3.363	0.610
Operation time (hour)	1.431	1.215–1.685	<0.001	1.237	1.007–1.520	0.042