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. 2018 Nov 14;3(6):e00587-18. doi: 10.1128/mSphere.00587-18

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Copyright © 2018 Lee et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — B. fragilis colonization regulates expression of proinflammatory cytokines and gene signatures associated with inflammation and tumor pathogenesis during colon cancer development in mice. (A) Expression levels of the indicated genes from colon homogenates of control, B. fragilis-colonized, or B. fragilis ΔPSA-colonized mice on day 81 of AOM-DSS treatment. Relative values were normalized to that of β-actin. (B) Immunofluorescent staining of CCR5 in colonic tissues of untreated control and B. fragilis-colonized mice on day 81 of AOM-DSS treatment. Data are representative of results from at least two experiments. Statistical significance was calculated using unpaired Student's t tests. *, P < 0.05 (in all panels).