FIG 1.
Growth of echinocandin-evolved strains in the presence of abiotic stressors. (A) Growth kinetics of parental C. parapsilosis CLIB 214 and echinocandin-evolved strains (CASEVO, ANDEVO, and MICAEVO). (B) Heat map of stress sensitivity and resistance to oxidative stress and cell wall and membrane perturbants. The asterisks indicate that C. parapsilosis CLIB 214 failed to grow in the presence of Congo red at 37°C, which precluded comparisons with evolved strains under this condition at this temperature. w/V, weight/volume. (C) Representative images of growth capabilities on YPD solid medium complemented with SDS, H2O2, and calcofluor white.