FIG 2.
In vivo virulence properties of C. parapsilosis CLIB 214, CASEVO, ANDEVO, and MICAEVO strains. (A) Survival proportion of Galleria mellonella infected with the parental strain and echinocandin-evolved strains. Experiments were repeated two times, and 20 larvae/group/experiment were used. Significant differences were determined with log rank tests. Two controls were run: PBS-treated (uninfected) and witness control (no injection, uninfected). (B) Fungal burden in the organs of BALB/c mice infected with CLIB 214, CASEVO, ANDEVO, or MICAEVO strain, represented in CFU/gram of tissue 3 days postinfection. Data points are means ± SEM pooled from three independent experiments (four BALB/c mice/group/experiment). Significant differences were determined by Mann-Whitney U-tests. *, P ≤ 0.05; **, P ≤ 0.005; ****, P ≤ 0.0001.