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. 2018 Oct 17;19(6):140–148. doi: 10.1002/acm2.12459

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© 2018 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Interplay effect in IMPT evaluated by the dose‐volume histogram indices, including (a) Normalized CTV D_95% and D_2 cc. (b) Normalized CTV D_5%‐D_95%. (c) Esophagus D_mean, total lung D_mean, spinal cord D_max, and heart D_mean. (d) Total lung V_5 Gy[ _RBE _] and V_20 Gy[ _RBE _], esophagus V_60 Gy[ _RBE _], and heart V_50 Gy[ _RBE _]. Abbreviations: RBE, relative biological effectiveness.