Fig. 5.

MMP and TIMP responses of LACV infected neuron/astrocyte co-cultures. Neuron/astrocyte co-cultures were either mock infected, treated with inactivated LACV, treated with Poly I:C, or infected with 0.1, 1, 10 MOI of LACV. a RNA was collected and analyzed via qRT-PCR against selected MMPs and TIMPs. Values are reported as fold change relative to mock treatment normalized to 18S RNA. b MMP activity assays were performed to determine MMP cleavage activity. *P < 0.5, **P < 0.01