Table 2.
Comparison of adverse events and serious adverse events between the low-dose and conventional-dose groups
| Type of event | Total | Low-dose | Conventional-dose |
|---|---|---|---|
| Number of patients | 39 | 20 | 19 |
| Adverse events | 35 (89.7) | 17 (85.0) | 18 (94.7) |
| Hypercholesterolaemia | 17 (43.6) | 7 (35.0) | 10 (52.6) |
| Stomatitis | 14 (35.9) | 10 (50.0)* | 4 (21.1) |
| URI | 9 (23.0) | 3 (15.0) | 6 (31.6) |
| Diarrhoea | 7 (17.9) | 4 (20.0) | 3 (15.8) |
| Headache | 5 (12.8) | 4 (20.0) | 1 (5.3) |
| Vaginal bleeding | 5 (12.8) | 1 (5.0) | 4 (21.1) |
| Acneiform lesions | 4 (10.3) | 3 (15.0) | 1 (5.3) |
| UTI | 4 (10.3) | 2 (10.0) | 2 (10.5) |
| Serious adverse events | 7 (17.9) | 3 (15.0) | 4 (21.1) |
| Infectiona | 4 (10.3) | 3 (15.0) | 1 (5.3) |
| Pneumothorax | 3 (7.7) | 1 (5.0) | 2 (10.5) |
| Malignancyb | 1 (2.3) | 0 (0.0) | 1 (5.3) |
Data are presented as number (%)
Abbreviations: URI upper respiratory infection, UTI urinary tract infection
*P < .1 (compared with conventional-dose group)
aInfection included pneumonia (n = 3) and cellulitis (n = 1)
bThyroid cancer