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. 2018 Nov 14;19:326. doi: 10.1186/s12882-018-1069-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Correlations between serum levels of tumor necrosis factor alpha (TNF-α) and different grade according to Oxford Classification ^a. (a) Serum levels of TNF-α were significantly higher in patients with mesangial hypercellularity grade M1 than that in patients with grade M0 [M1: 9.30 (7.90–10.60) pg/mL vs. M0: 6.70 (6.00–10.58) pg/mL, P = 0.03]. (d) Serum levels of TNF-α in patients with tubular atrophy/interstitial fibrosis grade T2 were significantly higher than that in grade T0 [T2: 10.60 (8.25–12.85) pg/mL vs. T0: 6.70 (6.00–10.58) pg/mL, P = 0.0005] and T1 [T2: 10.60 (8.25–12.85) pg/mL vs. T1: 9.20 (8.00–10.20) pg/mL, P = 0.02]; But there was no difference between patients with grade T1 and T0 (P = 0.05). (b, c and e) Serum levels of TNF-α in patients with different grades of endocapillary hypercellularity [E1: 9.35 (7.53–12.35) pg/mL vs. E0: 9.00 (7.75–10.60) pg/mL, P = 0.66], segmental glomerulosclerosis [S1: 9.40 (7.90–10.60) pg/mL vs. S0: 7.90 (6.20–10.68) pg/mL, P = 0.06] and cellular/fibrocellular crescents [C2:10.20 (7.00–14.50) pg/mL vs. C0: 9.00 (7.53–11.03) pg/mL, P = 0.22; C2: 10.20 (7.00–14.50) pg/mL vs. C1: 9.15 (7.80–10.50) pg/mL, P = 0.26; C1: 9.15 (7.80–10.50) pg/mL vs. C0: 9.00 (7.53–11.03) pg/mL, P = 0.81] did not show any significant difference. Statistically significant differences were tested with Mann–Whitney U-test. ^a Determined in accordance with the Oxford classification [5]