Table 1.

Functional annotation of two hub genes ITGA2 and MMP7

Genes	GO number	Biological process
ITGA2	GO:0045987	Positive regulation of smooth muscle contraction
	GO:0033591	Response to l-ascorbic acid
	GO:0031346	Positive regulation of cell projection organization
	GO:0043589	Skin morphogenesis
	GO:0048333	Mesodermal cell differentiation
	GO:0030198	Extracellular matrix organization
	GO:0007155	Cell adhesion
	GO:0042493	Response to drug
	GO:0007596	Blood coagulation
	GO:0007565	Female pregnancy
MMP7	GO:0006508	Proteolysis
	GO:0030574	Collagen catabolic process
	GO:0022617	Extracellular matrix disassembly
	GO:0007568	Aging