Fig. 3.

Exercise-responsive tumors demonstrate distinct metabolic differences. a Volcano plot showing fold changes in metabolites between control and exercise groups in the three exercise-responsive PDX models. Significantly altered metabolites (p < 0.05) determined using paired Student’s t test. b Heat map of integrated intensity values of the significantly altered metabolites between responsive control and exercise groups. c Corresponding impacted pathways as determined by the 15 significantly altered metabolites. d–h Key metabolic pathways broken down by individual metabolites. Error bars are representative of standard error of mean (SEM). * indicates p < 0.05, paired Student’s t test