Table 3.

Circulating miRNA expression levels before and after angioplasty in the angioplasty cohort, according to patent and restenosis groups at 6 months after angioplasty

miRNAs	Patent (n=32)		Restenosis (n=28)		P Value
MiR-21
Before	0.76	(0.23–2.08)	1.06	(0.30–5.45)	0.22
After	1.31	(0.40–4.16)	2.39	(1.11–12.62)	0.02
Δ(after-before)	0.22	(0.12–0.88)	0.91	(0.48–3.53)	<0.001
MiR-130a
Before	0.75	(0.24–2.67)	1.67	(0.65–4.40)	0.09
After	2.10	(1.08–6.32)	4.61	(2.34–7.18)	0.04
Δ(after-before)	1.14	(0.30–2.48)	1.97	(1.32–3.87)	0.04
MiR-221
Before	0.76	(0.14–3.35)	1.42	(0.43–10.31)	0.21
After	1.93	(0.51–4.92)	2.62	(1.49–15.73)	0.96
Δ(after-before)	0.50	(0.20–1.21)	0.82	(0.46–1.48)	0.21
MiR-222
Before	1.24	(0.28–3.37)	1.12	(0.57–1.63)	0.12
After	1.16	(0.35–2.71)	1.15	(0.49–1.75)	0.05
Δ(after-before)	−0.03	(−0.23 to 0.42)	0.16	(−0.44 to 0.79)	0.12
MiR-133
Before	3.23	(0.91–5.43)	3.01	(1.43–5.06)	0.69
After	2.19	(1.31–4.63)	4.47	(1.55–8.58)	0.30
Δ(after-before)	0.25	(−1.26 to 1.90)	2.27	(0.02–4.72)	0.11
MiR-145
Before	1.38	(0.28–4.13)	1.43	(0.75–3.23)	0.79
After	2.40	(0.96–6.16)	2.34	(1.13–5.38)	0.87
Δ(after-before)	1.07	(0.24–2.83)	0.67	(−0.13 to 4.02)	0.61

Data were expressed as median (interquartile range). Unit of miRNA expression levels: relative quantities, the relative expression level of miRNAs determined by the cycle number via quantitative real-time PCR, normalized to a control miRNA cel-miR-39 expression. miRNA, microRNA; Before, value before angioplasty; After, value 2 days after angioplasty; Δ (after-before): value 2 days after angioplasty minus value before angioplasty.