Table 1.
Baseline characteristics of patients admitted to the University of Pittsburgh Medical Center with hyponatremia and treated with urea between July 2016 and August 2017
| Characteristic | N=58 |
|---|---|
| Demographic characteristics | |
| Median age [IQR], yr | 68 [55–79] |
| Men, N (%) | 35 (60.3) |
| Clinical and treatment characteristics | |
| Etiology of hyponatremia, N (%) | |
| SIADHb | 47 (81) |
| Medications | 18 (31) |
| Idiopathic | 13 (22) |
| Intracranial disorders | 13 (22) |
| Malignancy | 10 (17) |
| Pulmonary disorders | 8 (14) |
| Pain | 7 (12) |
| Other | 2 (3) |
| Thiazide diuretics | 7 (12) |
| Heart failure | 6 (10) |
| Hypovolemia | 6 (10) |
| Kidney disease | 4 (7) |
| Adrenal insufficiency | 2 (3) |
| Cirrhosis | 1 (2) |
| Other therapies for hyponatremia, N (%) | |
| Fluid restriction | 51 (88) |
| Sodium chloride tablets | 22 (38) |
| Loop diuretics | 19 (33) |
| Normal saline | 12 (21) |
| Vasopressin antagonists | 6 (10) |
| Hypertonic saline 3% | 4 (7) |
| Potassium chloride tablets | 3 (5) |
| Glucocorticoids | 1 (2) |
Etiologies of hyponatremia and therapies for hyponatremia are not mutually exclusive. IQR, interquartile range; SIADH, syndrome of inappropriate antidiuretic hormone secretion.