Table 1.
Additional markers defining Treg subpopulations
| Marker | Positive (+) /Negative (−) | Related to |
|---|---|---|
| CD45RA | + | Naïve cells |
| CD45RO | + | Memory cells |
| ICOS | + | Production of IL-10 or TGF-β |
| CD39/73 | + | cAMP- or adenosine-mediated suppression |
| LAP | + | LAP/TGF-β complex in activated cells |
| CD103 | + | Effector and memory cells |
| GITR | + | Costimulatory |
| CD31 | + | Adhesion and transmigration |
| CD147 | + | Activated Treg |
| CCR4 | + | Migrate to the graft |
| CD49d | − | Part of lymphocyte homing receptor, useful for purification Tregs with CD127lo |
| CD62L | +/Low | Naïve cells/ effector and memory cells |
| CD161 | + | Proinflammatory potential |
| CTLA-4 | + | Coinhibitory molecule |
| CD71 | + | Activated Treg |
| GARP | + | Binds to TGF-β in activated cells |
| CD137 | + | Antigen-specific T cells |
ICOS, inducible costimulator; LAP, latency-associated peptide; GITR, glucocorticoid-induced TNF receptor; CCR4, C-C chemokine receptor type 4; CTLA-4, cytotoxic T lymphocyte antigen-4; GARP, glycoprotein A repetitions predominant.