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Effects of overuse activity on the supraspinatus tendon in a rat model. Decreases in tendon modulus (A) and changes in expression of 17 cartilage-specific genes (B) and 12 tendon-specific genes (C) in overuse animals compared to controls indicate tendon weakening and potential metaplasia of the supraspinatus into a more fibrocartilaginous phenotype with overuse.11,12 Reprinted with permission from Elsevier and John Wiley and Sons.
