Table 4.

Using Only the Nodules That Meet the QIBA CT Profile, the Mean of %Bias Estimates as a Function of Nodule Characteristics, and Reconstructed Slice Thickness

Shape Parameter	Size, HU Parameters	Semi-Automatic Type 1 Algorithm (%)	Semi-Automatic Type 2 Algorithm (%)	All (%)
Spherical	10 mm, −10 HU	3.07	3.72	3.39
		[−0.08, 6.21]	[0.56, 6.88]	[1.15, 5.63]
	10 mm, 100 HU*	1.36	−4.57	−1.60
		[−2.74, 5.46]	[−12.34, 3.21]	[−6.21, 3.01]
	20 mm, −10 HU	2.35	−2.95	−0.30
		[1.20, 3.49]	[−4.96, −0.94]	[−1.71, 1.11]
	20 mm, 100 HU	3.73	−2.11	0.81
		[2.51, 4.95]	[−3.65, −0.56]	[−0.37, 1.99]
	40 mm, −10 HU	0.19	−3.26	−1.54
		[−0.43, 0.81]	[−4.21, −2.31]	[−2.28, −0.79]
	40 mm, 100 HU	1.56	−0.28	0.64
		[−0.88, 2.24]	[−1.65, 1.09]	[−0.16, 1.45]
Elliptical	10 mm, −10 HU	9.34	−1.62	3.86
		[7.14, 11.54]	[−5.62, 2.38]	[1.24, 6.49]
	10 mm, 100 HU	11.36	4.86	8.11
		[3.81, 18.91]	[−2.82, 12.53]	[2.63, 13.8]
	20 mm, −10 HU	.73	−5.54	−1.41
		[1.68, 3.78]	[−8.10, −2.99]	[−3.14, 0.33]
	20 mm, 100 HU	6.66	20.03	13.34
		[5.56, 7.76]	[6.99, 33.08]	[6.65, 20.04]
Lobulated	10 mm, 10 HU	8.60	−25.10	−8.25
		[5.34, 11.86]	[−37.87, −12.33]	[−15.90, −0.60]
	10 mm, 100 HU	4.73	0.0008	2.36
		[2.25, 7.21]	[−4.03, 4.03]	[−0.08, 4.81]
	20 mm, −10 HU	0.47	−2.13	−0.83
		[−4.22, 5.17]	[−4.30, 0.03]	[−3.39, 1.73]
	20 mm, 100 HU	3.53	−3.06	0.23
		[2.22, 4.84]	[−4.83, −1.29]	[−1.14, 1.61]
Spiculated	10 mm, −10 HU	−5.15	−10.42	−7.78
		[−6.86, −3.43]	[−16.16, −4.68]	[−10.84, −4.73]
	10 mm, 100 HU	−2.00	−8.67	−5.34
		[−4.12, 0.11]	[−11.86, −5.49]	[−7.45, −3.23]
	20 mm, −10 HU	−1.76	−5.58	−4.94
		[−2.45, −1.11]	[−7.2, −3.97]	[−6.85,−3.03]
	20 mm, 100 HU	−2.90	−6.95	−4.92
		[−4.36, −1.44]	[−11.82, −2.07]	[−7.57, −2.28]
Irregular	10 mm, 100 HU	−2.10	−9.11	−5.60
		[−5.21, 1.01]	[−14.44, −3.77]	[−8.96, −2.25]
	12 mm, 20 HU*	−28.90	−11.50	−20.20
		[−36.94, −20.85]	[−72.52, 49.52]	[−49.63, 9.24]
All		1.89	−3.19	−0.65
		[1.05, 2.72]	[−5.04, −1.33]	[−1.66, 0.36]

CT, computed tomography; QIBA, Quantitative Imaging Biomarker Alliance.

Note: Results are tabulated across five semi-automated type 1and 5 semi-automated type 2 algorithms.

^*12 mm of irregular lesion with 20 HU and 10 mm of spherical lesion with 100 HU has only two lesions scans.