Table 5.

Deaths attributable to inborn errors of metabolism (IEM)

Author	Year	Location	Setting	% consanguinity	Total LB	IEM cases	Birth prev/ 105 LB	Deaths	Deaths/105 LB	Case fatality rate (%)
AlObaidy et al [13]	2013	Libya, Tripoli	Urban	86	156006	107	68.6	33	22.4	32.7
Dionisi-Vici et al [23]	2002	Italy, national survey	Urban-Rural	3	5336730	1935	36.3	356	6.4	18.4
Klose et al [32]	2002	Germany	Urban-Rural	N/A	844575	57	6.8	8	1.0	14.0
Couce et al [35]	2011	Spain, Galicia	Urban	N/A	210165	137	65.2	4	1.9	2.9
Frazier et al [36]	2006	USA, North Carolina	Urban	N/A	944078	219	23.3	7	0.7	3.2
Schulze et al [8]	2003	Germany	Urban-Rural	N/A	250000	106	42.4	3	1.2	2.8
Wilcken et al [42]	2009	Australia, national	Urban-Rural	N/A	1551200	115	7.4	26	1.7	22.6

N/A – not applicable, LB – live birth(s)