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Potential mechanisms explaining the effects of MTX on BP and arterial function in RA.
Abbreviations: MTX, methotrexate; FPGs, Folylpolyglutamate synthetase enzyme; ATIC, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; NO, nitric oxide; eNOS, endothelial NO synthase; PG, prostaglandins; cGMP, cyclic guanosine-3′, 5-monophosphate; GTP, guanosine-5′-triphosphate; BP, blood pressure; PWV, pulse wave velocity; RA, rheumatoid arthritis.
