Table 2.

Adjusted mean (95% CI) differences in BP, AIx, PWV, and concentrations of MTXPGs between CC (n=46) and AC (n=10) polymorphisms of the MTX ABCG2 SNP using combined data from baseline and 8 months

	Model 1		Model 2		Model 3
	β (95% CI)	P-value	β (95% CI)	P-value	β (95% CI)	P-value
Clinic peripheral SBP (mmHg)	6.2 (−3. 2, 15.5)	0.19	5.7 (−3.7, 15.1)	0.23	5.8 (−3.7, 15.4)	0.23
Clinic peripheral DBP (mmHg)	1.9 (−4.4, 8.4)	0.55	1.7 (−4.7, 8.05)	0.61	1.4 (−5.03, 7.7)	0.68
Clinic central SBP (mmHg)	7.3 (−1.7, 16.2)	0.11	7.0 (−2.0, 16.0)	0.13	7.02 (−2.1, 16.1)	0.13
Clinic central DBP (mmHg)	2.7 (−3.7, 9.0)	0.41	2.3 (−4.0, 8.7)	0.47	1.9 (−4.4, 8.2)	0.56
AIx @75 (%)	−1.1 (−6.5, 4.2)	0.68	−0.92 (−6.3, 4.4)	0.74	−0.81 (−6.2, 4.6)	0.77
24-hour peripheral SBP (mmHg)	7.6 (−1.9, 17)	0.12	7.1 (−2.3, 16.4)	0.14	7.2 (−2.2, 16.6)	0.13
24-hour peripheral DBP (mmHg)	3.9 (−1.3, 9.1)	0.14	3.5 (−1.6, 8.7)	0.18	3.4 (−1.8, 8.6)	0.20
24-hour central SBP (mmHg)	4 (−2.9, 11.0)	0.26	3.1 (−3.7, 9.8)	0.37	3.4 (−3.3, 10.0)	0.32
24-hour central DBP (mmHg)	1.8 (−2.2, 6.0)	0.38	1.4 (−2.7, 5.4)	0.52	1.6 (−2.5, 5.6)	0.45
24-hour AIx @75 (%)	1.3 (−2.5, 5.2)	0.50	1.3 (−2.5, 5.1)	0.50	1.6 (−2.2, 5.4)	0.42
24-hour PWV (m/second)	−0.04 (−0.74, 0.66)	0.97	−0.1 (−0.76, 0.63)	0.85	−0.1 (−76, 0.65)	0.89
MTXPGs (nmol/L)	26.2 (−12.1, 64.5)	0.18	27.7 (−10.6, 65.9)	0.16	27.9 (−11.2, 67.0)	0.16

Notes: Model 1 = adjusted for age and visit; Model 2 = adjusted for age, visit, gender, and BMI; Model 3 = adjusted for age, visit, gender, BMI, and DAS28.

Abbreviations: BMI, body mass index; MTX, Methotrexate; MTXPGs, MTX polyglutamates; BP, blood pressure; SBP, systolic BP; DBP, diastolic BP; AIx, Augmentation index; PWV, pulse wave velocity; DAS28, Disease Activity Score.