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. 2018 Jul 7;2(6):328–340. doi: 10.1002/jbm4.10058

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© 2018 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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OCs derived from RAW 264.7 cells have extended life spans compared with BMMs. (A) TRAP staining of OCs derived from RAW 264.7 cells and BMMs induced with M‐CSF and RANKL for 2 to 6 days. (B) The number of dead OCs were quantified and presented as a percentage of the total number of OCs. (C, D) TRAP staining of mature OCs depleted of M‐CSF and RANKL for 16 hours. (E) Percentage of TUNEL⁺ nuclei in mature OCs depleted of M‐CSF and RANKL for 16 hours. Scale bar = 1 mm. Data are means ± SD. Statistical analysis was performed using Student's t test (*p < 0.05, ***p < 0.001).