Figure 2. BLT1 deficiency reduces expression of proangiogenic and profibrotic factors in the laser-induced eyes.

(A) Quantitative PCR analysis of mRNA for various proangiogenic and profibrotic factors, cytokines, and chemokines in the eyes from aged BLT1-WT (white) and BLT1-KO (black) mice (>20 weeks old) on day 7 after laser injury. n = 3–6 per group. (B) Time-dependent changes in LTB₄ content in laser-injured eyes from young (white) and old (black) WT mice (young, 8 weeks old; old, >20 weeks old). n = 3–7 per group. *P < 0.05; **P < 0.01 (Student’s t test [A] and 1-way ANOVA with Bonferroni’s post hoc test [B]). Results are representative of at least 2 independent experiments.