Figure 6. T cells preferentially establish TCR/CD3 central cluster with MHCII⁺ cells in human GBM.

Percentages of infiltrated T cells interacting with either GFAP⁺ or MHCII⁺ cells in 3-D confocal scanning of GBM biopsies. (A) Infiltrated T cells establish interactions in the same proportion with GFAP⁺ and MHCII⁺ cells. (B) Interacting T cells establish TCR/CD3 cSMAC preferentially with MHCII⁺ cells. (C) An increase, although not significant, of the formation of flat interfaces can be observed between T cells and MHCII⁺ cells. (D) The percentage of T cells forming cSMAC is significantly higher when interacting with MHCII⁺ cells compared with GFAP⁺ cells. **P < 0.01, Student t test.