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. 2018 Sep 20;3(18):e121549. doi: 10.1172/jci.insight.121549

Figure 1. Morphologic analysis of muscle regeneration following acute sterile injury in naive and chronically infected muscle.

Figure 1

(A) Experimental design for CTX-induced injury during chronic T. gondii infection. (B) Representative wheat-germ agglutinin (WGA, green) and DAPI (blue) staining of naive (top) and chronically infected skeletal muscle (bottom) during CTX-induced injury at days 0 (no CTX), 1, 4, and 10 after injury. Scale bars: 100 μm. (C) Fiber size frequency distribution of naive and chronically infected skeletal muscle at day 0 (no CTX), 1, 4, and 10 after CTX-induced injury (n = 3 mice/group). (D) Average muscle fiber cross-sectional area at 10 days after CTX-induced injury in naive and infected mice (n ≥ 1,000 measurements/group from n = 4 mice/group). Results are representative of 3 experiments of n = 3–4/group/experiment; error bars represent SEM (C and D). ****P < 0.0001 by Kolmogorov-Smirnov (K-S) test (C) or Student’s t test (D).